An integrated in vivo and in silico analysis of the metabolism disrupting effects of CPI-613 on embryo-larval zebrafish (Danio rerio) - ScienceDirect
Devimistat (CPI-613) | デヒドロゲナーゼ 阻害剤
The Pyruvate Dehydrogenase Complex in Cancer: Implications for the Transformed State and Cancer Chemotherapy | IntechOpen
Frontiers | Metabolic Rewiring in Radiation Oncology Toward Improving the Therapeutic Ratio | Oncology
A comprehensive analysis of clinical trials in pancreatic cancer: what is coming down the pike? | Oncotarget
CPI-613 rewires lipid metabolism to enhance pancreatic cancer apoptosis via the AMPK-ACC signaling | Journal of Experimental & Clinical Cancer Research | Full Text
Cornerstone Pharmaceuticals Lead Compound CPI-613
A strategically designed small molecule attacks alpha-ketoglutarate dehydrogenase in tumor cells through a redox process | SpringerLink
Predictive targeting of mitochondrial metabolism in Acute Myeloid Leukemia patients with a lipoic acid analog | medRxiv
The Mitochondrion as an Emerging Therapeutic Target in Cancer: Trends in Molecular Medicine
CPI-613 rewires lipid metabolism to enhance pancreatic cancer apoptosis via the AMPK-ACC signaling | Journal of Experimental & Clinical Cancer Research | Full Text
A Phase II Clinical Trial of CPI-613 in Patients with Relapsed or Refractory Small Cell Lung Carcinoma
Cancers | Free Full-Text | The Metabolic Inhibitor CPI-613 Negates Treatment Enrichment of Ovarian Cancer Stem Cells
Safety and tolerability of the first-in-class agent CPI-613 in combination with modified FOLFIRINOX in patients with metastatic pancreatic cancer: a single-centre, open-label, dose-escalation, phase 1 trial - The Lancet Oncology
Devimistat – Drug Approvals International
Devimistat in combination with high dose cytarabine and mitoxantrone compared with high dose cytarabine and mitoxantrone in older patients with relapsed/refractory acute myeloid leukemia: ARMADA 2000 Phase III study | Future Oncology
Selectively Targeting Metabolism in Mitochondria In Cancer Cells | Cancer Biology