Chemistry lovers - The Cadiot–Chodkiewicz coupling The Cadiot–Chodkiewicz coupling in organic chemistry is a coupling reaction between a terminal alkyne and a haloalkyne catalyzed by a copper(I) salt such as copper(I) bromide
![Recent developments and applications of the Cadiot–Chodkiewicz reaction - Organic & Biomolecular Chemistry (RSC Publishing) DOI:10.1039/C5OB00697J Recent developments and applications of the Cadiot–Chodkiewicz reaction - Organic & Biomolecular Chemistry (RSC Publishing) DOI:10.1039/C5OB00697J](https://pubs.rsc.org/image/article/2015/OB/c5ob00697j/c5ob00697j-s12_hi-res.gif)
Recent developments and applications of the Cadiot–Chodkiewicz reaction - Organic & Biomolecular Chemistry (RSC Publishing) DOI:10.1039/C5OB00697J
![Gold‐Catalyzed Cadiot–Chodkiewicz‐type Cross‐Coupling of Terminal Alkynes with Alkynyl Hypervalent Iodine Reagents: Highly Selective Synthesis of Unsymmetrical 1,3‐Diynes - Li - 2017 - Angewandte Chemie International Edition - Wiley Online Library Gold‐Catalyzed Cadiot–Chodkiewicz‐type Cross‐Coupling of Terminal Alkynes with Alkynyl Hypervalent Iodine Reagents: Highly Selective Synthesis of Unsymmetrical 1,3‐Diynes - Li - 2017 - Angewandte Chemie International Edition - Wiley Online Library](https://onlinelibrary.wiley.com/cms/asset/1af697de-7cf5-45e2-9dad-292db73ce8c4/anie201702833-fig-5001-m.jpg)
Gold‐Catalyzed Cadiot–Chodkiewicz‐type Cross‐Coupling of Terminal Alkynes with Alkynyl Hypervalent Iodine Reagents: Highly Selective Synthesis of Unsymmetrical 1,3‐Diynes - Li - 2017 - Angewandte Chemie International Edition - Wiley Online Library
![Recent trends and applications of the Cadiot–Chodkiewicz reaction - Organic & Biomolecular Chemistry (RSC Publishing) DOI:10.1039/C9OB01757G Recent trends and applications of the Cadiot–Chodkiewicz reaction - Organic & Biomolecular Chemistry (RSC Publishing) DOI:10.1039/C9OB01757G](https://pubs.rsc.org/image/article/2019/OB/c9ob01757g/c9ob01757g-s13_hi-res.gif)
Recent trends and applications of the Cadiot–Chodkiewicz reaction - Organic & Biomolecular Chemistry (RSC Publishing) DOI:10.1039/C9OB01757G
![Cadiot–Chodkiewicz Active Template Synthesis of Rotaxanes and Switchable Molecular Shuttles with Weak Intercomponent Interactions - Berná - 2008 - Angewandte Chemie International Edition - Wiley Online Library Cadiot–Chodkiewicz Active Template Synthesis of Rotaxanes and Switchable Molecular Shuttles with Weak Intercomponent Interactions - Berná - 2008 - Angewandte Chemie International Edition - Wiley Online Library](https://onlinelibrary.wiley.com/cms/asset/6d3ccc8d-7815-4377-9eaf-db13ec1fa7c5/mcontent.jpg)
Cadiot–Chodkiewicz Active Template Synthesis of Rotaxanes and Switchable Molecular Shuttles with Weak Intercomponent Interactions - Berná - 2008 - Angewandte Chemie International Edition - Wiley Online Library
![Cadiot–Chodkiewicz Active Template Synthesis of Rotaxanes and Switchable Molecular Shuttles with Weak Intercomponent Interactions - Berná - 2008 - Angewandte Chemie - Wiley Online Library Cadiot–Chodkiewicz Active Template Synthesis of Rotaxanes and Switchable Molecular Shuttles with Weak Intercomponent Interactions - Berná - 2008 - Angewandte Chemie - Wiley Online Library](https://onlinelibrary.wiley.com/cms/asset/e73de397-345f-410d-a095-200c15d70905/nfor001.gif)
Cadiot–Chodkiewicz Active Template Synthesis of Rotaxanes and Switchable Molecular Shuttles with Weak Intercomponent Interactions - Berná - 2008 - Angewandte Chemie - Wiley Online Library
![Recent trends and applications of the Cadiot–Chodkiewicz reaction - Organic & Biomolecular Chemistry (RSC Publishing) DOI:10.1039/C9OB01757G Recent trends and applications of the Cadiot–Chodkiewicz reaction - Organic & Biomolecular Chemistry (RSC Publishing) DOI:10.1039/C9OB01757G](https://pubs.rsc.org/image/article/2019/OB/c9ob01757g/c9ob01757g-s3_hi-res.gif)
Recent trends and applications of the Cadiot–Chodkiewicz reaction - Organic & Biomolecular Chemistry (RSC Publishing) DOI:10.1039/C9OB01757G
![Recent trends and applications of the Cadiot–Chodkiewicz reaction - Organic & Biomolecular Chemistry (RSC Publishing) DOI:10.1039/C9OB01757G Recent trends and applications of the Cadiot–Chodkiewicz reaction - Organic & Biomolecular Chemistry (RSC Publishing) DOI:10.1039/C9OB01757G](https://pubs.rsc.org/image/article/2019/OB/c9ob01757g/c9ob01757g-s5_hi-res.gif)
Recent trends and applications of the Cadiot–Chodkiewicz reaction - Organic & Biomolecular Chemistry (RSC Publishing) DOI:10.1039/C9OB01757G
Full article: A convenient route to 1,3-diynes using ligand-free Cadiot-Chodkiewicz coupling reaction at room temperature under aerobic conditions
![Recent developments and applications of the Cadiot–Chodkiewicz reaction - Organic & Biomolecular Chemistry (RSC Publishing) DOI:10.1039/C5OB00697J Recent developments and applications of the Cadiot–Chodkiewicz reaction - Organic & Biomolecular Chemistry (RSC Publishing) DOI:10.1039/C5OB00697J](https://pubs.rsc.org/image/article/2015/OB/c5ob00697j/c5ob00697j-s3_hi-res.gif)
Recent developments and applications of the Cadiot–Chodkiewicz reaction - Organic & Biomolecular Chemistry (RSC Publishing) DOI:10.1039/C5OB00697J
![Scheme 3.1-mechanism for the copper(I) catalysed Cadiot-Chodkiewicz... | Download Scientific Diagram Scheme 3.1-mechanism for the copper(I) catalysed Cadiot-Chodkiewicz... | Download Scientific Diagram](https://www.researchgate.net/profile/Edward-Hems/publication/323556900/figure/fig15/AS:600824044597258@1520259023344/Scheme-31-mechanism-for-the-copperI-catalysed-Cadiot-Chodkiewicz-coupling-reaction-17.png)
Scheme 3.1-mechanism for the copper(I) catalysed Cadiot-Chodkiewicz... | Download Scientific Diagram
![Synthesis of 1,3-Diynes via Cadiot–Chodkiewicz Coupling of Volatile, in Situ Generated Bromoalkynes | Organic Letters Synthesis of 1,3-Diynes via Cadiot–Chodkiewicz Coupling of Volatile, in Situ Generated Bromoalkynes | Organic Letters](https://pubs.acs.org/cms/10.1021/acs.orglett.8b02975/asset/images/medium/ol-2018-02975s_0009.gif)