Of 72 antivirals tested in the laboratory, plitidepsin proves to be the most effective in preventing SARS-CoV-2 replication | IrsiCaixa
Aplidin, plitidepsin, as PM90001 | PharmaMar
Oncology clinical pipeline marine inspired drugs | PharmaMar
AplidinTM Induces Apoptosis in Human Cancer Cells via Glutathione Depletion and Sustained Activation of the Epidermal Growth Factor Receptor, Src, JNK, and p38 MAPK* - Journal of Biological Chemistry
Frontiers | Exploring the Diversity of the Marine Environment for New Anti-cancer Compounds | Marine Science
Plitidepsin | C57H87N7O15 - PubChem
Aplidin® induces JNK-dependent apoptosis in human breast cancer cells via alteration of glutathione homeostasis, Rac1 GTPase activation, and MKP-1 phosphatase downregulation | Cell Death & Differentiation
Plitidepsin: design, development, and potential place in therapy | DDDT
Role of Cu 2+ in Aplidin s -induced apoptosis in MDA-MB-231 cells | Download Table
Marine Drugs | Free Full-Text | Antitumor Peptides from Marine Organisms | HTML
New drugs in multiple myeloma: mechanisms of action and phase I/II clinical findings - The Lancet Oncology
Plitidepsin mechanism of action. | Download Scientific Diagram
Aplidin™ induces the mitochondrial apoptotic pathway via oxidative stress-mediated JNK and p38 activation and protein kinase C δ | Oncogene
Plitidepsin: a potential new treatment for relapsed/refractory multiple myeloma | Future Oncology
Dehydrodidemnin B - an overview | ScienceDirect Topics
Exploring the effect of aplidin on low molecular weight protein tyrosine phosphatase by molecular docking and molecular dynamic simulation study - ScienceDirect
Generation of endoplasmic reticulum stress and inhibition of autophagy by plitidepsin induces proteotoxic apoptosis in cancer cells - ScienceDirect
Oxidation and inactivation of low molecular weight protein tyrosine phosphatase by the anticancer drug Aplidin - Taddei - 2006 - International Journal of Cancer - Wiley Online Library
Plitidepsin has potent preclinical efficacy against SARS-CoV-2 by targeting the host protein eEF1A
Molecules | Free Full-Text | Approaches to the Potential Therapy of COVID-19: A General Overview from the Medicinal Chemistry Perspective | HTML
New drugs and novel mechanisms of action in multiple myeloma in 2013: a report from the International Myeloma Working Group (IMWG) | Leukemia
Dehydrodidemnin B - an overview | ScienceDirect Topics
Establishment and characterisation of a human carcinoma cell line with acquired resistance to Aplidin™ | British Journal of Cancer
Aplidin, plitidepsin, as PM90001 | PharmaMar
Repurposing anticancer drugs for the management of COVID-19 - ScienceDirect
